Susceptibility of <i>Toxoplasma gondii</i> to autophagy in human cells relies on multiple interacting parasite loci.

Recruitment of GFP-LC3 in naïve HeLa cells was low for all progeny, although there was an interesting trend that clones with high levels of recruitment in naïve cells were also the highest when treated with IFN-γ ( Fig. 2A ).

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When the variance associated with the ChrII locus was fixed as a covariate, the ChrVIII QTL was highly significant (6.81 LOD, marker AK50), and additionally, a second peak was observed on ChrVIIb, though this peak did not meet statistical significance ( P = 0.08, marker L363) ( Fig. 2D ; Tables 1 and S2).

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